Welsh Conservatives are facing up to big challenges as their party's UK conference begins in Birmingham today.
The issue of Brexit will no doubt dominate, as will speculation about an early UK General Election.
First Minister Carwyn Jones says Wales needs to be involved in negotiations about the UK's role in Europe. It follows the Prime Minister rejection of calls for Wales to be directly involved in Brexit talks.
As Theresa May attacks the Welsh Government's running of the NHS, Carwyn Jones accuses the Tories of "gutter politics" on immigration.
The Prime Minister has told ITV Cymru Wales that she will fully engage with the Welsh Government over Brexit negotiations.
The Treasury has agreed to take on the cost of EU aid spending approved by the Welsh Government in the period between Brexit and 2020.