MPs have voted by a majority of 372 to back the Government's plan to trigger Article 50 to begin the Brexit process by the end of March 2017.
Announcing the vote in the House of Commons, Speaker John Bercow, said that 461 had voted in favour, while 89 had voted against it.
MPs also voted in favour of a Labour amendment calling on the Government to publish its Brexit plan before formal talks begin no later than the end of March 2017.
There should be a referendum on the final Brexit deal secured by the Government, a Lib Dem MP has said.
Tom Brake, the MP for Carshalton and Wallington said: Why do people need a vote on the destination as well as the departure? Because whatever rough outline of a deal the Government manage to secure towards the end of the two years of negotiations after Article 50 has been invoked, we can be certain that a majority won't be happy.
"The 48% clearly won't be and what of the 52%?"
The Democratic presidential candidate may also have shown his cards on his choice of running mate.
The US president also shared a post on Twitter accusing Dr Anthony Fauci of misleading the public over hydroxychloroquine.
Fears over an impending second wave of coronavirus dominates Wednesday’s front pages.