MPs have voted by a majority of 372 to back the Government's plan to trigger Article 50 to begin the Brexit process by the end of March 2017.
Announcing the vote in the House of Commons, Speaker John Bercow, said that 461 had voted in favour, while 89 had voted against it.
MPs also voted in favour of a Labour amendment calling on the Government to publish its Brexit plan before formal talks begin no later than the end of March 2017.
MPs who voted to remain in the EU referendum should stop being labelled "remoaners" who wish to block Brexit, Conservative MP Anna Soubry has said.
The MP for Broxtowe in Nottinghamshire said that remainers would "accept and honour" the referendum's outcome and asked if leave MPs would "finally accept that?".
The remain campaigner added that while she did not "like the result [of the Brexit vote] and yes, I do believe the people made a terrible mistake", she would push for a Brexit deal with the best outcome for the UK.
The Democratic presidential candidate may also have shown his cards on his choice of running mate.
The US president also shared a post on Twitter accusing Dr Anthony Fauci of misleading the public over hydroxychloroquine.
Fears over an impending second wave of coronavirus dominates Wednesday’s front pages.