Air forces have carried out a fresh missile bombardment on rebel-held sections of Aleppo for the first time in three weeks, activists in the besieged city have said.
The British-based Syrian Observatory for Human Rights said the airstrikes struck three neighbourhoods.
There were no immediate details on casualties.
ITV News correspondent Dan Rivers, who recently returned from Aleppo, says that fresh airstrikes in the Syrian city feel "like an endgame" which may last months.
He said that Russia confirmed they were targeting ammunition depots, arms factories and training camps in Idlib province and Homs.
They did not say they were targeting rebel-held eastern Aleppo, although footage obtained earlier by ITV News appears to show airstrikes in that part of the city.
The Democratic presidential candidate may also have shown his cards on his choice of running mate.
The US president also shared a post on Twitter accusing Dr Anthony Fauci of misleading the public over hydroxychloroquine.
Fears over an impending second wave of coronavirus dominates Wednesday’s front pages.