Prescription drugs were found in Prince's possession when he died, according to US reports.
Officials told NBC News the painkillers were discovered in his Minneapolis home - but it is as yet unclear if they played any part in his death.
The pop star died aged 57 on April 21 after being found collapsed in a lift at his Paisley Park estate.
A four-hour post-mortem examination has been carried out on Prince's body following his sudden death on Thursday at the age of 57.
The singer's body will be released to his family later today, the Midwest Medical Examiner's Office said.
The painkillers were reportedly found in the singer's possession when he died - but it is unclear if they played any part in his death.
Mourners celebrate pop icon at private memorial at Paisley Park estate.
Star's ex-manager voiced concerns over whether whoever inherits the star's fortune, and valuable catalogue of works, will know what to do.