Forty-five migrants were taken by ferry from Lesbos to Turkey as Greek authorities restarted returns under an EU deal to stem the flow of migrants and refugees to Europe.
The ferry left the port of Mytilene on Friday morning, with a second boat expected to leave later, state television reported.
The first group of 202 migrants to be returned, most of them from Pakistan and Afghanistan, were taken back to Turkey on Monday.
Hundreds of migrants have been protesting in Lesbos today as they wait at a detention camp before being deported to Turkey.
ITV News' team in Lesbos caught them on camera as they chanted the word "freedom" over and over as they staged a sit-in at the Moira detention camp.
The Democratic presidential candidate may also have shown his cards on his choice of running mate.
The US president also shared a post on Twitter accusing Dr Anthony Fauci of misleading the public over hydroxychloroquine.
Fears over an impending second wave of coronavirus dominates Wednesday’s front pages.