World powers and Iran have formally announced a comprehensive nuclear accord.
Federica Mogherini, the European Union's foreign policy chief, said: "Today is an historic day."
She added that it was a great honour "for us to announce that we have reached an agreement on the Iranian nuclear issue".
Hassan Rouhani, the Iranian president, has welcomed the nuclear deal struck between his country and the six negotiating world powers, and urged regional neighbours to ignore Israeli "propaganda" about the deal.
He said the "win-win" deal would begin a new chapter of cooperation with the outside world after years of sanctions.
He said that Iran had a shared interest with its neighbours in the stability of the region and would abide by its commitments under the deal, as long as the other powers also did so.
The nuclear deal is a considerable triumph for Rouhani who has had to combat conservative factions at home while his foreign minister Mohammad Javad Zarif engaged in negotiations abroad.
The 66-year-old cleric had to keep up domestic support for an agreement and convince all sectors of Iranian society that it was in their interests.
Prime minister Netanyahu has likened the nuclear deal with Iran to the unsuccessful 1994 deal on North Korea's nuclear programme.
An end to Iranian nuclear question could soon be a reality after years of hard and often tense negotiations.