Joaquin "El Chapo" Guzman escaped a maximum security prison through a long tunnel discovered under his cell.
A nationwide manhunt is underway and a 60 million pesos (£2.4m) reward for information leading to the capture of the drug-runner has been posted.
Mexican prison and government authorities must have colluded with Joaquin "El Chapo" Guzman so that he could escape from a maximum security prison at the weekend, a key minister has said.
Interior Minister Miguel Angel Osorio Chong also insisted there would be "no rest" for El Chapo. offered a 60 million pesos (£2.4m) reward for information leading to the capture of the drug-runner.
The governor of the jail from where Guzman escaped has also been sacked, officials said.
Mexican authorities have released CCTV of the moment notorious drug lord 'El Chapo' escaped from prison - for the second time.
An escaped Mexican drug lord has reportedly threatened Donald Trump, prompting the billionaire businessman to contact the FBI.
Joaquin "El Chapo" Guzman escaped a maximum security prison through a long tunnel discovered under his cell.