President Obama has accepted the resignation of US Defence Secretary Chuck Hagel.
NBC reported the White House had "lost confidence" in Hagel to carry out his role at the Pentagon amid criticisms of Obama's national security team and the threat posed by IS.
Mr Hagel said he was "immensely proud" of what he and his colleagues had accomplished while he was US Defence Secretary.
US Defence Secretary Chuck Hagel has stepped down.
NBC reported the White House had "lost confidence" in Hagel to carry out his role at the Pentagon amid criticisms of Obama's national security team and the threat posed by IS.
According to one senior official: “He wasn’t up to the job.”
President Obama has accepted his resignation.
Hagel, the only Republican on the president's national security team and the first enlisted combat veteran to lead the Department of Defense, had served in the job since February 2013.
The Democratic presidential candidate may also have shown his cards on his choice of running mate.
The US president also shared a post on Twitter accusing Dr Anthony Fauci of misleading the public over hydroxychloroquine.
Fears over an impending second wave of coronavirus dominates Wednesday’s front pages.