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Protein 'fights cholesterol drugs'

Cholesterol-lowering drugs taken by millions of people may sometimes not work effectively because of a protein secreted by fat tissue, say scientists.

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Scientists discover protein link with cholesterol-lowering drugs

Dr Shirya Rashid, from McMaster University in Canada, who led the research into the effectiveness of cholesterol-lowering drugs, said:

The bigger implication of our results is that high blood resistin levels may be the cause of the inability of statins to lower patients' LDL cholesterol levels.

The discovery of resistin's role in raising cholesterol could lead to new therapeutic drugs that target the protein, she believes.

Dr Rashid's team showed that resistin increases the production of LDL in human liver cells, and reduced the liver's ability to clear "bad" cholesterol out of the body.

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