The North East and North Yorkshire has voted overwhelmingly to leave the EU with only Newcastle, Harrogate and York voting to remain.
See what politicians, businesses and organisations are saying in the wake of the UK exiting the EU
The Bishop of Durham has expressed his sadness after Britain voted in favour of leaving the European Union.
The Rt Rev Paul Butler was speaking during a visit to The Venerable Bede CE Academy in Sunderland as part of a Royal visit by the King and Queen of Lesotho. He said:
"I would personally like to thank the local community for their amazing donations of food, toiletries and clothing. "
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There has been resistance to calls to dismantle memorials to the explorer.