Violence triples at HMP Manchester
The report revealed there were 45 attacks on staff in just six months and 177 assaults in the same period.
Inspectors concluded the prison was "adequately resourced".
Michael Spurr, of HM Prison and Probation service, said: "Prison staff are working closely with police colleagues to tackle these issues."
Overall, the inspection by HM Inspectorate of Prisons (HMIP) found levels of violence to be "significant", with two-thirds of prisoners feeling unsafe during their time in the prison.A similar number indicated they had been "victimised by other prisoners" and over half "felt victimised by staff".
The use of force by staff had also "increased significantly" since the last inspection, and often "lacked sufficient scrutiny".
This contributed to an environment inspectors said was "less safe and respectful" than four years ago.