Tipuric rejoins Lions team mates Warburton and Faletau in the back row, while Evans and James add to their caps
Justin Tipuric joins captain Sam Warburton and Taulupe Faletaut to make an all-Lions back-row for Wales's Six Nations opener against Ireland.
Rob Evans starts at loose head earning his fourth Wales cap, while Tom James makes his first appearance in a red shirt since 2010 in the back line. He forms a new-look back three with Gareth Anscombe, who makes his Six Nations debut, and George North.
Jonathan Davies returns from injury to partner Jamie Roberts in the midfield - it'll be their 40th appearance together.
Dan Biggar and Gareth Davies line up together for the fifth time in a row at half-back. Evans is joined in the front-row by Scott Baldwin and Samson Lee and Luke Charteris and Alun Wyn Jones continue their second row partnership.
Bradley Davies will win his 50th cap if he comes off the bench. He's joined by Ken Owens, Gethin Jenkins, Tomas Francis, Lloyd Williams, Rhys Priestland and Alex Cuthbert in the replacements.
Wales team to face IrelandGareth Anscombe (Cardiff Blues), George North (Northampton Saints), Jonathan Davies (ASM Clermont), Jamie Roberts (Harlequins), Tom James (Cardiff Blues), Dan Biggar (Ospreys), Gareth Davies (Scarlets); Rob Evans (Scarlets), Scott Baldwin (Ospreys), Samson Lee (Scarlets), Luke Charteris (Racing 92), Alun Wyn Jones (Ospreys), Sam Warburton (Cardiff Blues, CAPT), Justin Tipuric (Ospreys), Taulupe Faletau (Newport Gwent Dragons).
Replacements: Ken Owens (Scarlets), Gethin Jenkins (Cardiff Blues), Tomas Francis (Exeter Chiefs), Bradley Davies (Wasps), Dan Lydiate (Ospreys), Lloyd Williams (Cardiff Blues), Rhys Priestland (Bath Rugby), Alex Cuthbert (Cardiff Blues).