Junior doctors are set to take part in the second day of the all-out strike in the row over contracts.
More than 20,000 junior doctors are thought to have been on strike yesterday as the Health Secretary admitted this was likely to be his "last big job in politics".
The strike is planned to take place between 8am and 5pm on Wednesday.
More than 100,000 outpatient appointments will be cancelled, and some 12,700 operations rescheduled, over the next two days as junior doctors across England take industrial strike action.
Preparations have been put in place for consultants to cover for junior staff members and staff will be deployed to worst affected areas but there are fears that some hospitals may still struggle.
ITV News health editor Rachel Younger reports:
As junior doctors walked out for a second day, how did hospitals cope? And will the strike action make any difference?
Labour leader Jeremy Corbyn was roundly cheered after joining thousands of junior doctors marching through Whitehall.
A baker has been handing out pasties to junior doctors at Truro Hospital in Cornwall, saying both his children owe their lives to the NHS.