Thee Cuban intelligence agents have been given heroes' welcomes as they landed back in their homeland after 16 years in prison in the US.
It comes as US President Barack Obama announced his country will restore diplomatic relations it severed with Cuba more than 50 years ago.
As part of a prisoner swap under the new policy, Cuba freed American Alan Gross in exchange for the three Cubans held by the United States.
Cuba has released American aid worker Alan Gross after five years in prison "on humanitarian grounds" at the request of the US, an official in Washington has said.
CNN reported a prisoner exchange that also included Cuba releasing a US intelligence source and the US releasing three Cuban intelligence agents.
Both President Barack Obama and Cuban President Raul Castro will make a statement at 5pm today on the agreement.
Gross, 65, a US Agency for International Development subcontractor, was arrested in December 2009.
He was later convicted to 15 years in prison for importing banned technology and trying to establish clandestine internet service for Cuban Jews.
The Democratic presidential candidate may also have shown his cards on his choice of running mate.
The US president also shared a post on Twitter accusing Dr Anthony Fauci of misleading the public over hydroxychloroquine.
Fears over an impending second wave of coronavirus dominates Wednesday’s front pages.