President Obama has accepted the resignation of US Defence Secretary Chuck Hagel.
NBC reported the White House had "lost confidence" in Hagel to carry out his role at the Pentagon amid criticisms of Obama's national security team and the threat posed by IS.
Mr Hagel said he was "immensely proud" of what he and his colleagues had accomplished while he was US Defence Secretary.
Barack Obama has said that Chuck Hagel has been "no ordinary" Secretary of Defence, adding that he has "been in the dirt and he has been in the mud".
The US President confirmed Mr Hagel will step down, but would remain in position until his successor is decided by the Senate.
The Democratic presidential candidate may also have shown his cards on his choice of running mate.
The US president also shared a post on Twitter accusing Dr Anthony Fauci of misleading the public over hydroxychloroquine.
Fears over an impending second wave of coronavirus dominates Wednesday’s front pages.